Research progress on the invasion and metastasis of tongue squamous cell carcinoma

Abstract

Tongue squamous cell carcinoma (TSCC) is the most common cancer of head and neck malignancies. Despite advances in therapeutic management, the prognosis for TSCC patients has remained poor. Local or regional relapse and cervical lymph node metastasis are clinical challenges. This review has introduced the research progress on cancer invasion and metastasis related genes, micro RNAs, EMT and cancer stem cells behavior and so on. With the further study on the mechanisms of invasion and metastasis of TSCC, the difficulties might be overcome.

Keywords

• Tongue，
• Squamous cell carcinoma，
• Invasion，
• Metastasis ，
• Tumor stem cells，