Long non-coding RNA RBM5-AS1 promotes the aggressive behaviors of oral squamous cell carcinoma by regulation of miR-1285-3p/YAP1 axis

Chenxi Li; Jishi Ye; Zhijun Zhang; Zhongcheng Gong; Zhaoquan Lin; Mingchao Ding

Biomedicine & Pharmacotherapy (Mar 2020)

Long non-coding RNA RBM5-AS1 promotes the aggressive behaviors of oral squamous cell carcinoma by regulation of miR-1285-3p/YAP1 axis

Chenxi Li,
Jishi Ye,
Zhijun Zhang,
Zhongcheng Gong,
Zhaoquan Lin,
Mingchao Ding

Affiliations

Chenxi Li: Department of Oral and Maxillofacial Surgery, Laboratory for Tumor Genetics and Regenerative Medicine, The Head and Neurocenter, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, 20246, Germany; Corresponding author at: Department of Oral and Maxillofacial Surgery, Laboratory for Tumor Genetics and Regenerative Medicine, The Head and Neurocenter, University Medical Center Hamburg-Eppendorf (UKE), Martinistrasse 52, Hamburg, 20246, Germany.
Jishi Ye: Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, PR China
Zhijun Zhang: Department of Dentofacial Surgery, Yantai Stomatological Hospital, 11 Songshan Road, Shandong Province, Yantai, 264000, PR China
Zhongcheng Gong: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province, Urumqi, 830054, PR China
Zhaoquan Lin: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province, Urumqi, 830054, PR China
Mingchao Ding: State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China; Corresponding author at: State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, No. 145 Changle Xi Road, Xi'an, 710032, PR China.

Journal volume & issue: Vol. 123
p. 109723

Abstract

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The human genome encodes far more long non-coding RNA (lncRNA) genes than protein coding genes. However, the function of majority of the lncRNAs is poorly understood. Numerous lncRNAs were aberrantly expressed in various cancers and found to be associated with development and progression of cancer. Little is known about the role of lncRNAs in oral squamous cell carcinoma (OSCC). In this study, we identified lncRNA RBM5-AS1 to be highly expressed in OSCC tumor tissues and cancer cell lines. RBM5-AS1 promotes the proliferation, migration, and invasion of OSCC cells in vitro. We also found that RBM5-AS1 regulates the level of miR-1285-3p as a competitive endogenous RNA (ceRNA), therefore regulate the expression level of an oncogene-YAP1, a target of miR-1285-3p. The information obtained in this study is valuable for understanding the regulatory mechanism of lncRNA in the development of OSCC and for developing new strategies for the diagnosis and treatment of OSCC.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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