Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
Wenwen Chen,
Zhongyu Li,
Pengwei Deng,
Zhengnan Li,
Yuhai Xu,
Hongjing Li,
Wentao Su,
Jianhua Qin
Affiliations
Wenwen Chen
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Zhongyu Li
College of Life Science, Dalian Minzu University, Dalian 116600, China
Pengwei Deng
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Zhengnan Li
Clinical Laboratory, Dalian University Affiliated Xinhua Hospital, Dalian 116021, China
Yuhai Xu
First Affiliated Hospital of Dalian Medical University, Dalian 116000, China
Hongjing Li
First Affiliated Hospital of Dalian Medical University, Dalian 116000, China
Wentao Su
School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China
Jianhua Qin
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer death in women worldwide. Although many factors associated with breast cancer have been identified, the definite etiology of breast cancer is still unclear. In addition, early diagnosis of breast cancer remains challenging. Exosomes are membrane-bound nanovesicles secreted by most types of cells and contain a series of biologically important molecules, such as lipids, proteins, and miRNAs, etc. Emerging evidence shows that exosomes can affect the status of cells by transmitting substances and messages among cells and are involved in various physiological and pathological processes. In breast cancer, exosomes play a significant role in breast tumorigenesis and progression through transfer miRNAs which can be potential biomarkers for early diagnosis of breast cancer. This review discusses the potential utility of exosomal miRNAs in breast cancer progression such as tumorigenesis, metastasis, immune regulation and drug resistance, and further in breast cancer diagnosis.
