Nature Communications (2019-07-01)

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

  • Mohammed Soutto,
  • Zheng Chen,
  • Ajaz A. Bhat,
  • Lihong Wang,
  • Shoumin Zhu,
  • Ahmed Gomaa,
  • Andreia Bates,
  • Nadeem S. Bhat,
  • Dunfa Peng,
  • Abbes Belkhiri,
  • M. Blanca Piazuelo,
  • M. Kay Washington,
  • Xi Chen Steven,
  • Richard Peek,
  • Wael El-Rifai

DOI
https://doi.org/10.1038/s41467-019-11011-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.