3D-Printed Composite Bone Bricks For Large Bone Tissue Applications

Daskalakis Evangelos; Liu Fengyuan; Acar Anil A.; Dinea Edera-Elena; Cooper Glen; Weightman Andrew; Koç Bahattin; Blunn Gordon; Jorge Bártolo Paulo

doi:10.1051/matecconf/202031801009

MATEC Web of Conferences (Jan 2020)

3D-Printed Composite Bone Bricks For Large Bone Tissue Applications

Daskalakis Evangelos,
Liu Fengyuan,
Acar Anil A.,
Dinea Edera-Elena,
Cooper Glen,
Weightman Andrew,
Koç Bahattin,
Blunn Gordon,
Jorge Bártolo Paulo

Affiliations

Daskalakis Evangelos: School of Mechanical, Aerospace and Civil Engineering, University of Manchester
Liu Fengyuan: School of Mechanical, Aerospace and Civil Engineering, University of Manchester
Acar Anil A.: Department of Manufacturing Engineering, Sabanci University
Dinea Edera-Elena: School of Mechanical, Aerospace and Civil Engineering, University of Manchester
Cooper Glen: School of Mechanical, Aerospace and Civil Engineering, University of Manchester
Weightman Andrew: School of Mechanical, Aerospace and Civil Engineering, University of Manchester
Koç Bahattin: Department of Manufacturing Engineering, Sabanci University
Blunn Gordon: School of Pharmacy and Biomedical Sciences, University of Portsmouth
Jorge Bártolo Paulo: School of Mechanical, Aerospace and Civil Engineering, University of Manchester

DOI: https://doi.org/10.1051/matecconf/202031801009
Journal volume & issue: Vol. 318
p. 01009

Abstract

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This study investigates the use of low cost, customizable, biodegradable, polymer-ceramic composite porous structures (bone bricks) for large bone tissue regeneration. Different ceramic materials (hydroxyapatite (HA), β-tri-calcium phosphate (TCP) and Bioglass (45S5) were mixed with poly-ε-caprolactone (PCL). Bone bricks with different material compositions were produced using an extrusion-based additive manufacturing system. Produced bone bricks were morphologically and mechanically assessed. Results allowed to establish a correlation between scaffolds architecture and material composition and scaffolds performance. Reinforced scaffolds showed improved mechanical properties. Best mechanical properties were obtained with PCL/TCP bone bricks and topologies based on 38 double zig zag filaments and 14 spirals.

Published in MATEC Web of Conferences

ISSN: 2261-236X (Online)
Publisher: EDP Sciences
Country of publisher: France
LCC subjects: Technology: Engineering (General). Civil engineering (General)
Website: http://www.matec-conferences.org

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