OncoTargets and Therapy (Sep 2019)
The Surgical Morbidity And Oncological Outcome Of Total Laparoscopic Radical Trachelectomy Versus Total Laparoscopic Radical Hysterectomy For Early Stage Cervical Cancer: A Retrospective Study With 11-Year Follow-Up
Abstract
Qi Lu, Zhiqiang Zhang, Meizhu Xiao, Chongdong Liu, Zhenyu Zhang Department of Obstetrics and Gynecology, Chao-yang Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Chongdong Liu; Zhenyu ZhangDepartment of Obstetrics and Gynecology, Beijing Chao-yang Hospital affiliated to Capital Medical University, 8 Gongtinanlu, Chaoyang District, Beijing 100020, People’s Republic of ChinaTel +86 10 13801237287Fax +86 10 85231507Email [email protected]; [email protected]: The objective of this study was to evaluate the surgical morbidity and oncological outcome of total laparoscopic radical trachelectomy (TLRT) and total laparoscopic radical hysterectomy (TLRH) in patients with early-stage cervical cancer.Methods: We performed a retrospective study to compare the outcomes of patients with stage IB1 cervical cancer who underwent TLRT to patients treated with TLRH from January 2005 to December 2016.Results: Forty-six patients underwent TLRT and 73 patients underwent TLRH between January 2005 and December 2016. The median age was 30 (19–40) years for TLRT group compared to 43 (31–65) years for TLRH group. No significant difference was found for the tumor size, histology, and pathology grade between TLRT group and TLRH group. In the TLRT group, the median operative time was 200 mins (range, 150–360 mins) and the median blood loss was 200 mL (range, 50–400mL). In the TLRH group, the median operative time was 240 mins (range, 180–380) and the median blood loss was 250mL (range, 10–1500mL). The median follow-up time was 80 months for TLRT group and 72 months for TLRH group. No patient in TLRT group developed recurrence. However, there were 2 recurrences diagnosed in the TLRH group.Conclusion: TLRT appears to have equal surgical morbidity and oncological outcome to TLRH in stage IB1 cervical cancer. Intraoperative complications did not differ significantly between these two groups. However, postoperative complications were fewer observed in TLRT. Because of the natural limitations of the retrospective study, the clinical value should be confirmed by multi-institutional prospective trial in the future.Keywords: cervical cancer, laparoscopic radical trachelectomy, laparoscopic radical hysterectomy, preserve fertility
