An Egg-Derived Sulfated <i>N</i> -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines

Abstract

Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an antigenic decoy, with egg-binding MAbs reacting with a sulfated N