mBio
(Jun 2021)
An Egg-Derived Sulfated
<i>N</i>
-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines
Jenna J. Guthmiller,
Henry A. Utset,
Carole Henry,
Lei Li,
Nai-Ying Zheng,
Weina Sun,
Marcos Costa Vieira,
Seth Zost,
Min Huang,
Scott E. Hensley,
Sarah Cobey,
Peter Palese,
Patrick C. Wilson
Affiliations
Jenna J. Guthmiller
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
Henry A. Utset
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
Carole Henry
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
Lei Li
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
Nai-Ying Zheng
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
Weina Sun
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Marcos Costa Vieira
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
Seth Zost
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Min Huang
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
Scott E. Hensley
ORCiD Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Sarah Cobey
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
Peter Palese
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Patrick C. Wilson
ORCiD Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
DOI
https://doi.org/10.1128/mBio.00838-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an antigenic decoy, with egg-binding MAbs reacting with a sulfated N
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