Nature Communications (May 2020)

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation

  • Peiyuan Zhang,
  • Yingjie Liu,
  • Cheng Lian,
  • Xuan Cao,
  • Yuan Wang,
  • Xiaoxun Li,
  • Min Cong,
  • Pu Tian,
  • Xue Zhang,
  • Gang Wei,
  • Tong Liu,
  • Guohong Hu

DOI
https://doi.org/10.1038/s41467-020-16051-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

Cancer stem-like cells are the culprits of tumour recurrence and metastasis, but their regulatory mechanisms are not fully understood. Here, the authors show that the scaffold protein SH3RF3 enhances the stem-like properties of breast cancer by facilitating activation of the JNK-JUN pathway and PTX3 expression.