Elevated Post-transplant Levels of Neopterin are Associated with Poorer long-term Graft Outcome

Abstract

Chronic allograft nephropathy (CAN) and death with functioning graft due to cardiovascular disease (CVD) are the key determinants for long-term renal allograft survival. Chronic allograft nephropathy and cardiovascular disease are seen as manifestations of a single disease entity with a common pathogenesis including inflammation and accelerated atherogenesis. Therefore we investigated the relation between early post-transplant inflammatory burden and long-term graft survival.

Keywords

• neopterin
• transplantation
• graft survival
• nephropathy