Nature Communications (Dec 2017)
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
- Chensu Wang,
- Hanspeter Niederstrasser,
- Peter M. Douglas,
- Rueyling Lin,
- Juan Jaramillo,
- Yang Li,
- Nathaniel W. Oswald,
- Anwu Zhou,
- Elizabeth A. McMillan,
- Saurabh Mendiratta,
- Zhaohui Wang,
- Tian Zhao,
- Zhiqaing Lin,
- Min Luo,
- Gang Huang,
- Rolf A. Brekken,
- Bruce A. Posner,
- John B. MacMillan,
- Jinming Gao,
- Michael A. White
Affiliations
- Chensu Wang
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Hanspeter Niederstrasser
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Peter M. Douglas
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Rueyling Lin
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Juan Jaramillo
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Yang Li
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Nathaniel W. Oswald
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Anwu Zhou
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Elizabeth A. McMillan
- Department of Cell Biology, University of Texas Southwestern Medical Center
- Saurabh Mendiratta
- Department of Cell Biology, University of Texas Southwestern Medical Center
- Zhaohui Wang
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Tian Zhao
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Zhiqaing Lin
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Min Luo
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Gang Huang
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Rolf A. Brekken
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Bruce A. Posner
- Department of Biochemistry, University of Texas Southwestern Medical Center
- John B. MacMillan
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Jinming Gao
- Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Michael A. White
- Department of Cell Biology, University of Texas Southwestern Medical Center
- DOI
- https://doi.org/10.1038/s41467-017-02332-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Activation of autophagy, via the transcription factor TFEB, is a promising strategy to treat metabolic diseases. Here, the authors report three novel classes of small molecules that promote TFEB nuclear translocation, and provide evidence for the therapeutic efficacy of these compounds in mice and worms.
