Mismatch negativity in tinnitus patient in relation to cortisol level

Abstract

Abstract Background The main aim of this study was the evaluation of mismatch negativity (MMN) in tinnitus patients in relation to serum cortisol levels. This study was designed to evaluate mismatch negativity (MMN) in tinnitus patients in relation to serum cortisol levels. For such purpose, MMN response and cortisol level were compared in tinnitus patients with normal hearing in comparison to normal hearing control. The methodology included full history taking, basic audiological evaluation, MMN, and the serum cortisol level measured at 9:00 am in addition to a tinnitus questionnaire in the study group only. Results There was a statistically significant delayed MMN latency in the study group in both the right and left ear in comparison to the control group. Regarding MMN amplitude, it was significantly reduced in the left ear in comparison to the left ear of the control. As regards the cortisol level, it was significantly increased in the study group when compared with the control group. Conclusion Mismatch negativity can be used to evaluate echoic memory in tinnitus patients. Additionally, serum cortisol levels can be used as an effective indicator of stress status and psychological condition in tinnitus patients.

Keywords

• Mismatch negativity
• Cortisol level
• Stress
• Tinnitus