Relationship between indoor inhalant allergen concentrations, serum IgE, and allergic diseases: A cross-sectional study from the NHANES 2005–2006 program

Fei Ye, MD; Gongkai He, MD; Hui Gan, MD

World Allergy Organization Journal (Feb 2024)

Relationship between indoor inhalant allergen concentrations, serum IgE, and allergic diseases: A cross-sectional study from the NHANES 2005–2006 program

Fei Ye, MD,
Gongkai He, MD,
Hui Gan, MD

Affiliations

Fei Ye, MD: Otolaryngology Department of Huangpu People's Hospital of Zhongshan, Allergy Department/Otolaryngology Head and Neck Surgery Department of Zhongshan City People's Hospital, China
Gongkai He, MD: Xinxiang Medical University, Zhongshan City People's Hospital, China
Hui Gan, MD: Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University (The Key Laboratory of Advanced Interdisciplinary Studies Center, Advanced Interdisciplinary Studies Center), Guangzhou, China; Corresponding author: Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 510180, Guangzhou, Guangdong, China

Journal volume & issue: Vol. 17, no. 2
p. 100866

Abstract

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This research analyzed data from 5106 participants in the National Health and Nutrition Examination Survey 2005–2006 to explore the link between indoor allergen concentrations, serum IgE levels, and allergic diseases. The study found that 14.9% of participants reported having asthma, with significant differences noted in the concentrations of certain indoor allergens, specifically dust dog, mite, and cat allergens, between asthma and non-asthma groups. Furthermore, positivity rates for inhalant allergen-specific IgE and total IgE were higher in the asthma group. However, the correlations between most inhalant allergen IgE, including total IgE, and indoor allergen concentrations were very weak. These findings suggest that the relationship between indoor allergen concentrations and asthma incidence is complex, indicating a potential need for personalized allergen prevention strategies based on disease type and patient sensitization.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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