Variable Loci of the <i>napA</i>, <i>rhaS</i>, <i>zwf</i> and <i>tcaB</i> Genes as Effective DNA-Targets for <i>Yersinia pestis</i> Strains Genotyping

Abstract

Variability of the nucleotide sequences of the napA, rhaS, zwf and tcaB genes was elucidated in natural Yersinia pestis strains of the main and non-main subspecies from different natural plague foci. Use of variable loci of these genes enables to carry out intra-species differentiation of plague microbe strains and attribute the studied strain to certain subspecies or biovar.

Keywords

• plague agent
• variability of genes
• molecular typing