Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development

C. C. Kurashova; A. A. Ishmukhametov; M. C. Egorova; M. V. Balovneva; T. K. Dzagurova; E. A. Tkachenko

doi:10.31631/2073-3046-2018-17-4-26-29

Эпидемиология и вакцинопрофилактика (Sep 2018)

Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development

C. C. Kurashova,
A. A. Ishmukhametov,
M. C. Egorova,
M. V. Balovneva,
T. K. Dzagurova,
E. A. Tkachenko

Affiliations

C. C. Kurashova: Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»
A. A. Ishmukhametov: Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»$ Sechenov First Moscow State Medical University, of the Ministry of Healthcare of the Russian Federation
M. C. Egorova: Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»
M. V. Balovneva: Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»
T. K. Dzagurova: Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»
E. A. Tkachenko: Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»$ Sechenov First Moscow State Medical University, of the Ministry of Healthcare of the Russian Federation

DOI: https://doi.org/10.31631/2073-3046-2018-17-4-26-29
Journal volume & issue: Vol. 17, no. 4
pp. 26 – 29

Abstract

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The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Essential advantage of UV and BPL in relation to formaldehyde is the short time of virus inactivation.

Published in Эпидемиология и вакцинопрофилактика

ISSN: 2073-3046 (Print); 2619-0494 (Online)
Publisher: Numikom LLC
Country of publisher: Russian Federation
LCC subjects: Philosophy. Psychology. Religion: Speculative philosophy: Epistemology. Theory of knowledge
Website: https://www.epidemvac.ru

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