Nature Communications (Dec 2017)

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

  • Andrea Romagnani,
  • Valentina Vettore,
  • Tanja Rezzonico-Jost,
  • Sarah Hampe,
  • Elsa Rottoli,
  • Wiebke Nadolni,
  • Michela Perotti,
  • Melanie A. Meier,
  • Constanze Hermanns,
  • Sheila Geiger,
  • Gunther Wennemuth,
  • Camilla Recordati,
  • Masayuki Matsushita,
  • Susanne Muehlich,
  • Michele Proietti,
  • Vladimir Chubanov,
  • Thomas Gudermann,
  • Fabio Grassi,
  • Susanna Zierler

DOI
https://doi.org/10.1038/s41467-017-01960-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells