Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Giuseppe Bersani; Pietropaolo Marino; Giuseppe Valeriani; Valentina Cuoco; Claudia Zitelli; Claudia Melcore; Francesco Saverio Bersani

doi:10.1155/2013/926395

Case Reports in Psychiatry (Jan 2013)

Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Giuseppe Bersani,
Pietropaolo Marino,
Giuseppe Valeriani,
Valentina Cuoco,
Claudia Zitelli,
Claudia Melcore,
Francesco Saverio Bersani

Affiliations

Giuseppe Bersani: Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy
Pietropaolo Marino: Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy
Giuseppe Valeriani: Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy
Valentina Cuoco: Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy
Claudia Zitelli: Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy
Claudia Melcore: Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy
Francesco Saverio Bersani: Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy

DOI: https://doi.org/10.1155/2013/926395
Journal volume & issue: Vol. 2013

Abstract

Read online

Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.

Published in Case Reports in Psychiatry

ISSN: 2090-682X (Print); 2090-6838 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://onlinelibrary.wiley.com/journal/1604

About the journal