Effect of Peganum harmala seeds alcoholic extract on kidney efficiency, thyroid stimulating hormone and thyroid gland hormones in local female rabbits

Abstract

Peganum harmala belong to the Jigo phalluses family has many compounds as alkaloids, Saponines steroids and lignin which are used as a medicinal components which serve as a regulator to endocrine activity, in this study, twenty adult female local rabbits with weighing 1500±100gms, and aged 240 ±10 days were divided into 2 groups: the control group which fed on diet and water ad libitum and the treatment group which administrated orally (by stomach tube) 10cc with 13.5% of peganum harmala alcoholic extract daily for 14 consecutive days, and at the 15th day, blood samples were collected. Serum level of Triiodothyronine (T3), Thyroxin (T4) and Thyroid-stimulating hormone (TSH), uric acid and creatinine were measured by using radioimmunoassay method. Results were revealed that the 90mg/kg dosage of peganum harmala alcoholic extract increased significantly (p<0.05) the levels of the urea and uric acid when compared with control, while the creatinine has not recorded significant variances when compared with the control group, on the other hand, the effect of Peganum harmala seed alcoholic extract on the TSH, T3, T4 levels revealed that these hormones decreased significantly (p<0.05) when compared with the control group. In conclusion the results of this study indicate that the 90mg/kg of an alcoholic extract of Peganum harmala seeds has increased blood urea and uric acid, decreased blood TSH as well as hormones of thyroid gland