Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach

Abstract

A new approach to the total synthesis of (−)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.

Keywords

• epimyrtine
• gold
• gold catalysis
• heterocycles
• hydroamination
• quinolizidine alkaloid
• total synthesis