Nature Communications (Nov 2022)
High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection
- Eva-Maria Jacobsen,
- Dorit Fabricius,
- Magdalena Class,
- Fernando Topfstedt,
- Raquel Lorenzetti,
- Iga Janowska,
- Franziska Schmidt,
- Julian Staniek,
- Maria Zernickel,
- Thomas Stamminger,
- Andrea N. Dietz,
- Angela Zellmer,
- Manuel Hecht,
- Peter Rauch,
- Carmen Blum,
- Carolin Ludwig,
- Bernd Jahrsdörfer,
- Hubert Schrezenmeier,
- Maximilian Heeg,
- Benjamin Mayer,
- Alina Seidel,
- Rüdiger Groß,
- Jan Münch,
- Frank Kirchhoff,
- Sebastian F. N. Bode,
- Gudrun Strauss,
- Hanna Renk,
- Roland Elling,
- Maximillian Stich,
- Reinhard E. Voll,
- Burkhard Tönshof,
- Axel R. Franz,
- Philipp Henneke,
- Klaus-Michael Debatin,
- Marta Rizzi,
- Ales Janda
Affiliations
- Eva-Maria Jacobsen
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Dorit Fabricius
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Magdalena Class
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Fernando Topfstedt
- Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg
- Raquel Lorenzetti
- Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg
- Iga Janowska
- Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg
- Franziska Schmidt
- Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg
- Julian Staniek
- Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg
- Maria Zernickel
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Thomas Stamminger
- Institute of Virology, Ulm University Medical Center
- Andrea N. Dietz
- Institute of Virology, Ulm University Medical Center
- Angela Zellmer
- CANDOR Bioscience GmbH
- Manuel Hecht
- CANDOR Bioscience GmbH
- Peter Rauch
- CANDOR Bioscience GmbH
- Carmen Blum
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Carolin Ludwig
- Department of Transfusion Medicine, Ulm University
- Bernd Jahrsdörfer
- Department of Transfusion Medicine, Ulm University
- Hubert Schrezenmeier
- Department of Transfusion Medicine, Ulm University
- Maximilian Heeg
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Benjamin Mayer
- Department of Statistics, University of Ulm
- Alina Seidel
- Institute of Molecular Virology, Ulm University Medical Center
- Rüdiger Groß
- Institute of Molecular Virology, Ulm University Medical Center
- Jan Münch
- Institute of Molecular Virology, Ulm University Medical Center
- Frank Kirchhoff
- Institute of Molecular Virology, Ulm University Medical Center
- Sebastian F. N. Bode
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Gudrun Strauss
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Hanna Renk
- University Children’s Hospital Tuebingen
- Roland Elling
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Maximillian Stich
- Department of Pediatrics I, University Children’s Hospital Heidelberg
- Reinhard E. Voll
- Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg
- Burkhard Tönshof
- Department of Pediatrics I, University Children’s Hospital Heidelberg
- Axel R. Franz
- University Children’s Hospital Tuebingen
- Philipp Henneke
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Klaus-Michael Debatin
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Marta Rizzi
- Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg
- Ales Janda
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- DOI
- https://doi.org/10.1038/s41467-022-35055-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Severity of SARS-CoV-2 infection is different in adults and children which involves the immune response. Here using a parent and children cohort with 4 month and 12 month sampling times, the authors show enhanced levels and increased breadth of anti-spike antibody level over time but reduced specific T cell and B cell numbers in children.
