Emerging Infectious Diseases (Jan 2012)

Molecular Evolution of Respiratory Syncytial Virus Fusion Gene, Canada, 2006–2010

  • Jesse Papenburg,
  • Julie Carbonneau,
  • Marie-Ève Hamelin,
  • Sandra Isabel,
  • Xavier Bouhy,
  • Najwa Ohoumanne,
  • Pierre Déry,
  • Bosco A. Paes,
  • Jacques Corbeil,
  • Michel G. Bergeron,
  • Gaston De Serres,
  • Guy Boivin

DOI
https://doi.org/10.3201/eid1801.110515
Journal volume & issue
Vol. 18, no. 1
pp. 120 – 124

Abstract

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To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006–2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients.

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