(11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione

Abstract

The title chiral compound, C13H14N2O4, was prepared by an intracyclization reaction of methyl (S)-1-(4-hydroxy-5-methoxy-2-nitrobenzyl)-5-oxopyrrolidine-2-carboxylate in the presence of ethanol and iron. The five-membered substituted pyrrole ring adopts an approximate envelope conformation, while the seven-membered substituted diazepine ring displays a twist-boat conformation. Intermolecular O—H...O and N—H...O hydrogen bonding helps to stabilize the crystal structure.