PLoS ONE (Jan 2021)

Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease.

  • Stephen Franklin Weng,
  • Ralph Kwame Akyea,
  • Kenneth Kc Man,
  • Wallis C Y Lau,
  • Barbara Iyen,
  • Joseph Edgar Blais,
  • Esther W Chan,
  • Chung Wah Siu,
  • Nadeem Qureshi,
  • Ian C K Wong,
  • Joe Kai

DOI
https://doi.org/10.1371/journal.pone.0260839
Journal volume & issue
Vol. 16, no. 12
p. e0260839

Abstract

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BackgroundVariability in low-density lipoprotein cholesterol (LDL-C) response to statins is underappreciated. We characterised patients by their statin response (SR), baseline risk of cardiovascular disease (CVD) and 10-year CVD outcomes.Methods and resultsA multivariable model was developed using 183,213 United Kingdom (UK) patients without CVD to predict probability of sub-optimal SR, defined by guidelines as ConclusionsPatients with sub-optimal response to statins experienced significantly more MACE, regardless of baseline CVD risk. To enhance cholesterol management for primary prevention, statin response should be considered alongside risk assessment.