Cancers (Mar 2022)
Advanced Magnetic Resonance Imaging (MRI) Techniques: Technical Principles and Applications in Nanomedicine
- Federico Bruno,
- Vincenza Granata,
- Flavia Cobianchi Bellisari,
- Ferruccio Sgalambro,
- Emanuele Tommasino,
- Pierpaolo Palumbo,
- Francesco Arrigoni,
- Diletta Cozzi,
- Francesca Grassi,
- Maria Chiara Brunese,
- Silvia Pradella,
- Maria Luisa Mangoni di S. Stefano,
- Carmen Cutolo,
- Ernesto Di Cesare,
- Alessandra Splendiani,
- Andrea Giovagnoni,
- Vittorio Miele,
- Roberto Grassi,
- Carlo Masciocchi,
- Antonio Barile
Affiliations
- Federico Bruno
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Vincenza Granata
- Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, Italy
- Flavia Cobianchi Bellisari
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Ferruccio Sgalambro
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Emanuele Tommasino
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Pierpaolo Palumbo
- Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy
- Francesco Arrigoni
- Emergency and Interventional Radiology, San Salvatore Hospital, 67100 L’Aquila, Italy
- Diletta Cozzi
- Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy
- Francesca Grassi
- Department of Precision Medicine, University of Campania “L. Vanvitelli”, 81100 Naples, Italy
- Maria Chiara Brunese
- Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
- Silvia Pradella
- Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy
- Maria Luisa Mangoni di S. Stefano
- Dipartimento di Laboratorio di Analisi e dei Servizi, Azienda Sanitaria Locale Napoli 3 Sud, 80059 Napoli, Italy
- Carmen Cutolo
- Department of Emergency and General Surgery, University of Salerno, 84100 Salerno, Italy
- Ernesto Di Cesare
- Department of Life, Health and Enviromental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Alessandra Splendiani
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Andrea Giovagnoni
- Departement of Radiological Sciences, Ospedali Riuniti Ancona, Università Politecnica Delle Marche, University Hospital, Via Tronto 10, 60126 Ancona, Italy
- Vittorio Miele
- Division of Radiodiagnostic, Azienda Ospedaliero-Universitaria Careggi, 50134 Firenze, Italy
- Roberto Grassi
- Department of Precision Medicine, University of Campania “L. Vanvitelli”, 81100 Naples, Italy
- Carlo Masciocchi
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Antonio Barile
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- DOI
- https://doi.org/10.3390/cancers14071626
- Journal volume & issue
-
Vol. 14,
no. 7
p. 1626
Abstract
In the last decades, nanotechnology has been used in a wide range of biomedical applications, both diagnostic and therapeutic. In this scenario, imaging techniques represent a fundamental tool to obtain information about the properties of nanoconstructs and their interactions with the biological environment in preclinical and clinical settings. This paper reviews the state of the art of the application of magnetic resonance imaging in the field of nanomedicine, as well as the use of nanoparticles as diagnostic and therapeutic tools, especially in cancer, including the characteristics that hinder the use of nanoparticles in clinical practice.
Keywords
- nanomedicine
- nanoparticles
- magnetic resonance imaging
- dynamic contrast enhancement
- diffusion weighted imaging
- contrast media
