Nature Communications (Nov 2021)

Directed nickel-catalyzed regio- and diastereoselective arylamination of unactivated alkenes

  • Leipeng Xie,
  • Shenghao Wang,
  • Lanlan Zhang,
  • Lei Zhao,
  • Chun Luo,
  • Linping Mu,
  • Xiuguang Wang,
  • Chao Wang

DOI
https://doi.org/10.1038/s41467-021-26527-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Few methods exist to add a carbon and nitrogen atom across an unfunctionalized alkene. Here the authors show a method to regio- and diastereoselectively add aryl and amino groups to terminal and internal alkenes, via nickel catalysis and a removable directing group.