Nature Communications (Jul 2024)
Improving laboratory animal genetic reporting: LAG-R guidelines
- Lydia Teboul,
- James Amos-Landgraf,
- Fernando J. Benavides,
- Marie-Christine Birling,
- Steve D. M. Brown,
- Elizabeth Bryda,
- Rosie Bunton-Stasyshyn,
- Hsian-Jean Chin,
- Martina Crispo,
- Fabien Delerue,
- Michael Dobbie,
- Craig L. Franklin,
- Ernst-Martin Fuchtbauer,
- Xiang Gao,
- Christelle Golzio,
- Rebecca Haffner,
- Yann Hérault,
- Martin Hrabe de Angelis,
- Kevin C. Kent Lloyd,
- Terry R. Magnuson,
- Lluis Montoliu,
- Stephen A. Murray,
- Ki-Hoan Nam,
- Lauryl M. J. Nutter,
- Eric Pailhoux,
- Fernando Pardo Manuel de Villena,
- Kevin Peterson,
- Laura Reinholdt,
- Radislav Sedlacek,
- Je Kyung Seong,
- Toshihiko Shiroishi,
- Cynthia Smith,
- Toru Takeo,
- Louise Tinsley,
- Jean-Luc Vilotte,
- Søren Warming,
- Sara Wells,
- C. Bruce Whitelaw,
- Atsushi Yoshiki,
- Asian Mouse Mutagenesis Resource Association,
- CELPHEDIA infrastructure,
- INFRAFRONTIER consortium,
- International Mammalian Genome Society,
- International Mouse Phenotyping Consortium,
- International Society for Transgenic Technologies,
- Mutant Mouse Resource and Research Centers,
- Phenomics Australia,
- RRRC- Rat Resource and Research Center,
- Guillaume Pavlovic
Affiliations
- Lydia Teboul
- The Mary Lyon Centre at MRC Harwell, Harwell Campus
- James Amos-Landgraf
- University of Missouri School of Medicine
- Fernando J. Benavides
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Marie-Christine Birling
- PHENOMIN-Institut Clinique de la Souris, CELPHEDIA, CNRS, INSERM, Université de Strasbourg, Illkirch-Grafenstaden
- Steve D. M. Brown
- Visiting Scientist, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Grafenstaden
- Elizabeth Bryda
- Rat Resource and Research Center, University of Missouri
- Rosie Bunton-Stasyshyn
- The Mary Lyon Centre at MRC Harwell, Harwell Campus
- Hsian-Jean Chin
- National Laboratory Animal Center (NLAC), NARLabs
- Martina Crispo
- Laboratory Animal Biotechnology Unit, Institut Pasteur de Montevideo, Mataojo 2020
- Fabien Delerue
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Michael Dobbie
- Phenomics Australia, Australian National University
- Craig L. Franklin
- University of Missouri Mutant Mouse Resource and Research Center (MU MMRRC), University of Missouri
- Ernst-Martin Fuchtbauer
- Department of Molecular Biology, University of Aarhus
- Xiang Gao
- National Resource Center of Mutant Mice (NRCMM), Nanjing Biomedical Research Institute, Nanjing University
- Christelle Golzio
- Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258
- Rebecca Haffner
- Department Veterinary Resources, Weizmann Institute of Science
- Yann Hérault
- PHENOMIN-Institut Clinique de la Souris, CELPHEDIA, CNRS, INSERM, Université de Strasbourg, Illkirch-Grafenstaden
- Martin Hrabe de Angelis
- Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstraße 1
- Kevin C. Kent Lloyd
- Mouse Biology Program, University of California Davis
- Terry R. Magnuson
- Department of Genetics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Lluis Montoliu
- Department of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC)
- Stephen A. Murray
- The Jackson Laboratory
- Ki-Hoan Nam
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Lauryl M. J. Nutter
- Genetics and Genome Biology, The Hospital for Sick Children and The Centre for Phenogenomics
- Eric Pailhoux
- Université Paris-Saclay, UVSQ, INRAE, BREED
- Fernando Pardo Manuel de Villena
- Department of Genetics, University of North Carolina
- Kevin Peterson
- The Jackson Laboratory
- Laura Reinholdt
- The Jackson Laboratory
- Radislav Sedlacek
- Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences
- Je Kyung Seong
- Laboratory of Developmental Biology and Genomics, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, and Korea Mouse Phenotyping Center
- Toshihiko Shiroishi
- RIKEN BioResource Research Center (BRC)
- Cynthia Smith
- Mouse Genome Informatics (MGI), Jackson Laboratory
- Toru Takeo
- Center for Animal Resources and Development (CARD), Institute of Resource Development and Analysis, Kumamoto University
- Louise Tinsley
- The Mary Lyon Centre at MRC Harwell, Harwell Campus
- Jean-Luc Vilotte
- Université Paris-Saclay, INRAE, AgroParisTech, GABI
- Søren Warming
- Genentech, Inc., a member of the Roche group
- Sara Wells
- The Mary Lyon Centre at MRC Harwell, Harwell Campus
- C. Bruce Whitelaw
- The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
- Atsushi Yoshiki
- Experimental Animal Division, RIKEN BioResource Research Center
- Asian Mouse Mutagenesis Resource Association
- CELPHEDIA infrastructure
- INFRAFRONTIER consortium
- International Mammalian Genome Society
- International Mouse Phenotyping Consortium
- International Society for Transgenic Technologies
- Mutant Mouse Resource and Research Centers
- Phenomics Australia
- RRRC- Rat Resource and Research Center
- Guillaume Pavlovic
- PHENOMIN-Institut Clinique de la Souris, CELPHEDIA, CNRS, INSERM, Université de Strasbourg, Illkirch-Grafenstaden
- DOI
- https://doi.org/10.1038/s41467-024-49439-y
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 8
Abstract
Abstract The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals’ genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.
