Frontiers in Cell and Developmental Biology (Jul 2021)
Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications
- Hao Li,
- Hao Li,
- Hao Li,
- Hao Li,
- Pinxue Li,
- Pinxue Li,
- Pinxue Li,
- Pinxue Li,
- Zhen Yang,
- Zhen Yang,
- Zhen Yang,
- Zhen Yang,
- Cangjian Gao,
- Cangjian Gao,
- Cangjian Gao,
- Cangjian Gao,
- Liwei Fu,
- Liwei Fu,
- Liwei Fu,
- Liwei Fu,
- Zhiyao Liao,
- Zhiyao Liao,
- Zhiyao Liao,
- Zhiyao Liao,
- Tianyuan Zhao,
- Tianyuan Zhao,
- Tianyuan Zhao,
- Tianyuan Zhao,
- Fuyang Cao,
- Fuyang Cao,
- Fuyang Cao,
- Wei Chen,
- Wei Chen,
- Wei Chen,
- Wei Chen,
- Yu Peng,
- Zhiguo Yuan,
- Xiang Sui,
- Xiang Sui,
- Xiang Sui,
- Shuyun Liu,
- Shuyun Liu,
- Shuyun Liu,
- Quanyi Guo,
- Quanyi Guo,
- Quanyi Guo,
- Quanyi Guo
Affiliations
- Hao Li
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Hao Li
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Hao Li
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Hao Li
- School of Medicine, Nankai University, Tianjin, China
- Pinxue Li
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Pinxue Li
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Pinxue Li
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Pinxue Li
- School of Medicine, Nankai University, Tianjin, China
- Zhen Yang
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Zhen Yang
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Zhen Yang
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Zhen Yang
- School of Medicine, Nankai University, Tianjin, China
- Cangjian Gao
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Cangjian Gao
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Cangjian Gao
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Cangjian Gao
- School of Medicine, Nankai University, Tianjin, China
- Liwei Fu
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Liwei Fu
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Liwei Fu
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Liwei Fu
- School of Medicine, Nankai University, Tianjin, China
- Zhiyao Liao
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Zhiyao Liao
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Zhiyao Liao
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Zhiyao Liao
- School of Medicine, Nankai University, Tianjin, China
- Tianyuan Zhao
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Tianyuan Zhao
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Tianyuan Zhao
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Tianyuan Zhao
- School of Medicine, Nankai University, Tianjin, China
- Fuyang Cao
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Fuyang Cao
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Fuyang Cao
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Wei Chen
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Wei Chen
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Wei Chen
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Wei Chen
- School of Medicine, Nankai University, Tianjin, China
- Yu Peng
- School of Medicine, Nankai University, Tianjin, China
- Zhiguo Yuan
- Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Xiang Sui
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Xiang Sui
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Xiang Sui
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Shuyun Liu
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Shuyun Liu
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Shuyun Liu
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Quanyi Guo
- The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China
- Quanyi Guo
- Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
- Quanyi Guo
- Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China
- Quanyi Guo
- School of Medicine, Nankai University, Tianjin, China
- DOI
- https://doi.org/10.3389/fcell.2021.661802
- Journal volume & issue
-
Vol. 9
Abstract
Knee menisci are structurally complex components that preserve appropriate biomechanics of the knee. Meniscal tissue is susceptible to injury and cannot heal spontaneously from most pathologies, especially considering the limited regenerative capacity of the inner avascular region. Conventional clinical treatments span from conservative therapy to meniscus implantation, all with limitations. There have been advances in meniscal tissue engineering and regenerative medicine in terms of potential combinations of polymeric biomaterials, endogenous cells and stimuli, resulting in innovative strategies. Recently, polymeric scaffolds have provided researchers with a powerful instrument to rationally support the requirements for meniscal tissue regeneration, ranging from an ideal architecture to biocompatibility and bioactivity. However, multiple challenges involving the anisotropic structure, sophisticated regenerative process, and challenging healing environment of the meniscus still create barriers to clinical application. Advances in scaffold manufacturing technology, temporal regulation of molecular signaling and investigation of host immunoresponses to scaffolds in tissue engineering provide alternative strategies, and studies have shed light on this field. Accordingly, this review aims to summarize the current polymers used to fabricate meniscal scaffolds and their applications in vivo and in vitro to evaluate their potential utility in meniscal tissue engineering. Recent progress on combinations of two or more types of polymers is described, with a focus on advanced strategies associated with technologies and immune compatibility and tunability. Finally, we discuss the current challenges and future prospects for regenerating injured meniscal tissues.
Keywords
- polymeric scaffold
- natural polymer
- synthetic polymer
- meniscal tissue engineering
- meniscal regeneration
