Nature Communications (Feb 2023)
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer
- Lulu Sun,
- Yi Zhang,
- Jie Cai,
- Bipin Rimal,
- Edson R. Rocha,
- James P. Coleman,
- Chenran Zhang,
- Robert G. Nichols,
- Yuhong Luo,
- Bora Kim,
- Yaozong Chen,
- Kristopher W. Krausz,
- Curtis C. Harris,
- Andrew D. Patterson,
- Zhipeng Zhang,
- Shogo Takahashi,
- Frank J. Gonzalez
Affiliations
- Lulu Sun
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- Yi Zhang
- Department of General Surgery, Cancer Center, Peking University Third Hospital
- Jie Cai
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- Bipin Rimal
- Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary & Biomedical Sciences, Pennsylvania State University
- Edson R. Rocha
- Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University
- James P. Coleman
- Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University
- Chenran Zhang
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Robert G. Nichols
- Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary & Biomedical Sciences, Pennsylvania State University
- Yuhong Luo
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- Bora Kim
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- Yaozong Chen
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- Kristopher W. Krausz
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- Curtis C. Harris
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Andrew D. Patterson
- Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary & Biomedical Sciences, Pennsylvania State University
- Zhipeng Zhang
- Department of General Surgery, Cancer Center, Peking University Third Hospital
- Shogo Takahashi
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- Frank J. Gonzalez
- Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-023-36089-9
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Non-enterotoxigenic Bacteroides fragilis (NTBF) is abundant in colorectal cancer (CRC) patients and in a high-fat diet (HFD)-induced CRC model. Here the authors show that bile salt hydrolase-expressing NTBF is enriched in CRC patients with overweight and promotes tumor growth in an HFD-induced CRC mouse model.
