Direct Cross-Coupling of Alcohols with <i>O</i>-Nucleophiles Mediated by <i>N</i>-Iodosuccinimide as a Precatalyst under Mild Reaction Conditions

Abstract

We report N-iodosuccinimide as the most efficient and selective precatalyst among the N-halosuccinimides for dehydrative O-alkylation reactions between various alcohols under high-substrate concentration reaction conditions. The protocol is non-metal, one-pot, selective, and easily scalable, with excellent yields; enhancing the green chemical profiles of these transformations.

Keywords

• alcohols
• <i>N</i>-iodosuccinimide
• cross-coupling
• etherification
• green chemistry