Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone
Xia Yan,
Xi-Xiang Tang,
Lin Chen,
Zhi-Wei Yi,
Mei-Juan Fang,
Zhen Wu,
Ying-Kun Qiu
Affiliations
Xia Yan
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
Xi-Xiang Tang
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China
Lin Chen
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
Zhi-Wei Yi
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China
Mei-Juan Fang
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
Zhen Wu
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
Ying-Kun Qiu
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.
