Relationship between left ventricular mechanical synchrony and left ventricular systolic function: a CZT-SPECT analysis

Abstract

Abstract Background CZT-SPECT has good agreement in the evaluation of mechanical synchronization compared with conventional SPECT. The aim of this study was to evaluate the correlation between left ventricular mechanical contraction synchrony and left ventricular systolic function by gated myocardial perfusion imaging (GMPI) using cadmium–zine–telluride (CZT) single photon emission computed tomography (SPECT). Methods This retrospective study involved 371 patients (239 males and 132 females, mean age 61.06 ± 11.78 years old) who underwent GMPI at the Nuclear Medicine Department of Shanxi Cardiovascular Hospital from January 2020 to August 2020. Systolic synchrony parameters and left ventricular systolic function parameters were calculated via Emory Cardiac Toolbox, including PP, PSD, PHB, HS, HK, EDV, ESV, and LVEF. Based on LVEF value, patients were divided into the severe reduction group (group 1, 127 cases, EF 0.001). PP was significantly higher in group 1, relative to group 3 (t = 2.43, P 0.001). HS and HK were negatively correlated with EDV and ESV (r = − 0.700 to − 0.594, P < 0.001). Conclusion CZT SPECT GMPI provided left ventricular mechanical contraction synchrony parameters that correlated well with left ventricular systolic function. Worse left ventricular mechanical contraction synchrony lead to decreased LVEF, making the systolic synchrony parameters valuable in the prediction of left ventricular systolic function.

Keywords

• Systolic function
• Mechanical synchronization
• CZT-SPECT