Evolution of high-level resistance during low-level antibiotic exposure

Erik Wistrand-Yuen; Michael Knopp; Karin Hjort; Sanna Koskiniemi; Otto G. Berg; Dan I. Andersson

doi:10.1038/s41467-018-04059-1

Nature Communications (Apr 2018)

Evolution of high-level resistance during low-level antibiotic exposure

Erik Wistrand-Yuen,
Michael Knopp,
Karin Hjort,
Sanna Koskiniemi,
Otto G. Berg,
Dan I. Andersson

Affiliations

Erik Wistrand-Yuen: Department of Medical Biochemistry and Microbiology, Uppsala University
Michael Knopp: Department of Medical Biochemistry and Microbiology, Uppsala University
Karin Hjort: Department of Medical Biochemistry and Microbiology, Uppsala University
Sanna Koskiniemi: Department of Cell and Molecular Biology, Uppsala University
Otto G. Berg: Department of Cell and Molecular Biology, Uppsala University
Dan I. Andersson: Department of Medical Biochemistry and Microbiology, Uppsala University

DOI: https://doi.org/10.1038/s41467-018-04059-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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