Tk-deleted pseudorabies virus retains high pathogenicity in rats

Zhang Lirong; Ruan Keyue; Sang Guoju; Xu Zhaoyang; Tong Wu; Yu Hai; Shan Tongling; Gao Fei; Li Liwei; Kong Ning; Tong Guangzhi; Zheng Hao

doi:10.2478/jvetres-2021-0056

Journal of Veterinary Research (Oct 2021)

Tk-deleted pseudorabies virus retains high pathogenicity in rats

Zhang Lirong,
Ruan Keyue,
Sang Guoju,
Xu Zhaoyang,
Tong Wu,
Yu Hai,
Shan Tongling,
Gao Fei,
Li Liwei,
Kong Ning,
Tong Guangzhi,
Zheng Hao

Affiliations

Zhang Lirong: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Ruan Keyue: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Sang Guoju: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Xu Zhaoyang: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Tong Wu: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Yu Hai: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Shan Tongling: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Gao Fei: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Li Liwei: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Kong Ning: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Tong Guangzhi: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China
Zheng Hao: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, China

DOI: https://doi.org/10.2478/jvetres-2021-0056
Journal volume & issue: Vol. 65, no. 4
pp. 401 – 405

Abstract

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The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats.

Published in Journal of Veterinary Research

ISSN: 2450-8608 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Agriculture: Animal culture: Veterinary medicine
Website: https://sciendo.com/journal/JVETRES

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