Airway hyperresponsiveness in bronchial asthma: pathogenesis basics

Abstract

Bronchial asthma has three main components: persistent bronchial inflammation, reversible bronchial obstruction and bronchial hyperresponsiveness to nonspecific triggers. Airway hyperresponsiveness is a complex phenomenon that develops upon the influence of chronic inflammation, high total IgE, changes in bronchial smooth muscle cells functioning, structural changes in bronchial wall and disturbances in neural regulation of bronchial tone.

Keywords

• бронхиальная астма
• бронхиальная гиперреактивность
• атопическое воспаление