Long noncoding RNA LINC01419 promotes hepatocellular carcinoma malignancy by mediating miR‐485‐5p/LSM4 axis

Abstract

Abstract To investigate the effect of long noncoding RNA (LINC01419)/miR‐485‐5p/LSM4 on the malignant behavior of hepatocellular carcinoma (HCC) cells. The expressions of LINC01419, miR‐485‐5p, and LSM4 were determined in HCC at the cellular and clinical levels, and cell biological behavior was evaluated. The relationships between LINC01419, miR‐485‐5p, and LSM4 were predicted and verified. Additionally, the subcellular localization of LINC01419 in HCC cells was analyzed. Finally, an animal experiment was conducted to confirm the effect of LINC01419 silencing on tumor growth. in HCC tissues and cells, LINC01419 and LSM4 were increasingly expressed, but miR‐485‐5p was decreasingly expressed. LINC01419 negatively regulated miR‐485‐5p‐ and miR‐485‐5p‐targeted LSM4. LINC01419 was localized in the cytoplasm of HCC cells. Downregulation of miR‐485‐5p or upregulation of LSM4 reversed the inhibition of HCC cell malignant behavior by LINC01419 interference. LINC01419 sponges miR‐485‐5p to upregulate LSM4 expression, thereby facilitating the biological behavior of HCC cells.

Keywords

• hepatocellular carcinoma
• long noncoding RNA LINC01419
• LSM4
• miR‐485‐5p
• proliferation