Communications Biology (Oct 2021)

Features of repertoire diversity and gene expression in human cytotoxic T cells following allogeneic hematopoietic cell transplantation

  • Hideki Nakasone,
  • Machiko Kusuda,
  • Kiriko Terasako-Saito,
  • Koji Kawamura,
  • Yu Akahoshi,
  • Masakatsu Kawamura,
  • Junko Takeshita,
  • Shunto Kawamura,
  • Nozomu Yoshino,
  • Kazuki Yoshimura,
  • Yukiko Misaki,
  • Ayumi Gomyo,
  • Kazuaki Kameda,
  • Masaharu Tamaki,
  • Aki Tanihara,
  • Shun-ichi Kimura,
  • Shinichi Kako,
  • Yoshinobu Kanda

DOI
https://doi.org/10.1038/s42003-021-02709-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 18

Abstract

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Cytomegalovirus reactivation is an important concern after allogeneic stem cell transplantation (allo-HCT) or organ transplantation. Here, Hideki Nakasone et al. investigate changes in repertoire diversity and gene expression among clinically-transferred T cells to improve our understanding of immune reconstitution following allo-HCT.