Assessing drug-drug interactions: Prevalence, predictors, and their impact on in-hospital mortality in hospitalised haemodialysis patients

Abstract

This retrospective observational study was conducted in Libya to examine the frequency and determinants of drug-drug interactions (DDIs) among hospitalised haemodialysis inpatients between January 2018 and June 2020. The study highlighted a notable prevalence of DDIs among HD patients, with a prevalence rate of 71.1%. Regarding the identification of DDI predictors and their correlations with extended hospital stays and polypharmacy, regression analysis was conducted to identify predictors and outcomes. The study found that DDIs were associated with prolonged hospital stays and were independently linked to polypharmacy in HD patients. Furthermore, a significant clinical impact of DDIs on HD patients was observed, particularly in relation to in-hospital mortality.