Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis

Shenyi Yin; Yu Fan; Hanshuo Zhang; Zhihua Zhao; Yang Hao; Juan Li; Changhong Sun; Junyu Yang; Zhenjun Yang; Xiao Yang; Jian Lu; Jianzhong Jeff Xi

doi:10.1038/ncomms11012

Nature Communications (Mar 2016)

Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis

Shenyi Yin,
Yu Fan,
Hanshuo Zhang,
Zhihua Zhao,
Yang Hao,
Juan Li,
Changhong Sun,
Junyu Yang,
Zhenjun Yang,
Xiao Yang,
Jian Lu,
Jianzhong Jeff Xi

Affiliations

Shenyi Yin: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University
Yu Fan: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University
Hanshuo Zhang: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University
Zhihua Zhao: State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking University
Yang Hao: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University
Juan Li: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University
Changhong Sun: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University
Junyu Yang: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University
Zhenjun Yang: School of Pharmaceutical Sciences, Peking University
Xiao Yang: State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology
Jian Lu: College of Life Science, Peking University
Jianzhong Jeff Xi: Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University

DOI: https://doi.org/10.1038/ncomms11012
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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MiR-122 levels correlate with metastasis in human liver cancer but not in mouse models. Here the authors show that miR-122 targets TGFßR1 in mice but TGFß1 in humans, that swapping this specificity affects metastasis, and that many other receptor-ligand pairs are differentially targeted by miRNAs across species.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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