The Anti-Inflammatory, Analgesic, and Antioxidant Effects of Polyphenols from <i>Brassica oleracea var. capitata</i> Extract on Induced Inflammation in Rodents
Octavia Sabin,
Raluca Maria Pop,
Ioana Corina Bocșan,
Veronica Sanda Chedea,
Floricuța Ranga,
Adriana Grozav,
Antonia-Mihaela Levai,
Anca Dana Buzoianu
Affiliations
Octavia Sabin
Pharmacology Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, “Iuliu Haţieganu” University of Medicine and Pharmacy, Victor Babeș, No. 8, 400012 Cluj-Napoca, Romania
Raluca Maria Pop
Pharmacology Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, “Iuliu Haţieganu” University of Medicine and Pharmacy, Victor Babeș, No. 8, 400012 Cluj-Napoca, Romania
Ioana Corina Bocșan
Pharmacology Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, “Iuliu Haţieganu” University of Medicine and Pharmacy, Victor Babeș, No. 8, 400012 Cluj-Napoca, Romania
Veronica Sanda Chedea
Research Station for Viticulture and Enology Blaj (SCDVV Blaj), 515400 Blaj, Romania
Floricuța Ranga
Food Science and Technology, Department of Food Science, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăștur, No. 3-5, 400372 Cluj-Napoca, Romania
Adriana Grozav
Department of Organic Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Antonia-Mihaela Levai
Obstetrics and Gynecology, Department of Mother and Child, “Iuliu Hatieganu” University of Medicine and Pharmacy, Victor Babeș, No. 8, 400012 Cluj-Napoca, Romania
Anca Dana Buzoianu
Pharmacology Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, “Iuliu Haţieganu” University of Medicine and Pharmacy, Victor Babeș, No. 8, 400012 Cluj-Napoca, Romania
This study investigates the anti-inflammatory, analgesic, and antioxidant properties of polyphenols extracted from Brassica oleracea var. capitata (cabbage) ethanolic extract (BOE). Given the historical use of cabbage in traditional medicine for treating various ailments, this research aims to validate these effects scientifically. The study involved the characterization of BOE’s bioactive compounds using Fourier Transform Infrared Spectroscopy (FTIR) and Liquid Chromatography–Diode Array Detection–Electro-Spray Ionization Mass Spectrometry (HPLC-DAD-ESI MS) analysis. We assessed the anti-inflammatory and analgesic effects of topical and oral BOE administration on rodent models with acute and subacute inflammation. Additionally, the antioxidant capacity of orally administered BOE was evaluated. The results showed that BOE possesses significant levels of phenolic compounds with a potent antioxidant activity. The topical administration of BOE demonstrated notable anti-inflammatory effects in the tested rodent models, which were comparable with nonsteroidal anti-inflammatory drugs. These findings suggest that BOE could be a valuable natural remedy for inflammation-related conditions, supporting its traditional uses and highlighting its potential for further pharmacological development.
