Long-term depression in neurons involves temporal and ultra-structural dynamics of phosphatidylinositol-4,5-bisphosphate relying on PIP5K, PTEN and PLC

Sarah A. Hofbrucker-MacKenzie; Eric Seemann; Martin Westermann; Britta Qualmann; Michael M. Kessels

doi:10.1038/s42003-023-04726-0

Communications Biology (Apr 2023)

Long-term depression in neurons involves temporal and ultra-structural dynamics of phosphatidylinositol-4,5-bisphosphate relying on PIP5K, PTEN and PLC

Sarah A. Hofbrucker-MacKenzie,
Eric Seemann,
Martin Westermann,
Britta Qualmann,
Michael M. Kessels

Affiliations

Sarah A. Hofbrucker-MacKenzie: Institute of Biochemistry I, Jena University Hospital — Friedrich Schiller University Jena
Eric Seemann: Institute of Biochemistry I, Jena University Hospital — Friedrich Schiller University Jena
Martin Westermann: Center for Electron Microscopy, Jena University Hospital — Friedrich Schiller University Jena
Britta Qualmann: Institute of Biochemistry I, Jena University Hospital — Friedrich Schiller University Jena
Michael M. Kessels: Institute of Biochemistry I, Jena University Hospital — Friedrich Schiller University Jena

DOI: https://doi.org/10.1038/s42003-023-04726-0
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 15

Abstract

Read online

Ultrahigh-resolution views of PIP2 in freeze-fractured plasma membranes of dendritic spines during induction of long-term depression reveal spatial and temporal cues set by PIP2 and reveal the molecular mechanisms behind the observed PIP2 dynamics

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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