Future Science OA (Dec 2022)

The expression profiling of serum miR-92a, miR-134 and miR-375 in acute ischemic stroke

  • Aya Tarek Salman,
  • Olfat Shaker,
  • Shereen Saeid Elshaer,
  • Ahmed Elshafei

DOI
https://doi.org/10.2144/fsoa-2022-0074
Journal volume & issue
Vol. 8, no. 10

Abstract

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Aim: To investigate the expression profile and diagnostic potentials of serum miR-92a, 134, and 375 in acute ischemic stroke (AIS) patients. Materials & methods: Serum miRs-92a, 134, and 375 expression profiles were estimated by qRT-PCR for 70 AIS patients, age-matched with 25 control subjects. Their diagnostic potential was estimated by ROC analysis. Results: Down-expression of miR-92a and miR-375 was found (56; 96.5%; -1.86 ± 1.36; and 53; 91.4%; -1.63 ± 1.38, respectively), while miR-134 showed a predominant upregulation (46; 79.3%; 0.853 ± 1.34). The diagnostic accuracy was the highest for miR-92a and miR-375 (area under the curve = 0.9183 and 0.898, respectively), with greater specificity for miR-375 (Sp = 96%). Conclusion: Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.

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