Effects of kynurenic acid and choline on lipopolysaccharide-induced cyclooxygenase pathway

Baris Elif; Simsek Oguzhan; Yoca Ozge Uysal; Demir Ayse Banu; Tosun Metiner

doi:10.1515/tjb-2023-0017

Türk Biyokimya Dergisi (Jun 2023)

Effects of kynurenic acid and choline on lipopolysaccharide-induced cyclooxygenase pathway

Baris Elif,
Simsek Oguzhan,
Yoca Ozge Uysal,
Demir Ayse Banu,
Tosun Metiner

Affiliations

Baris Elif: Department of Medical Pharmacology, Faculty of Medicine, Izmir University of Economics, Izmir, Türkiye
Simsek Oguzhan: Department of Pharmacology, Institute of Health Sciences, Dokuz Eylul University, Izmir, Türkiye
Yoca Ozge Uysal: Department of Medical Biology and Genetics, Institute of Health Sciences, Dokuz Eylul University, Izmir, Türkiye
Demir Ayse Banu: Department of Medical Biology, Faculty of Medicine, Izmir University of Economics, Izmir, Türkiye
Tosun Metiner: Department of Medical Pharmacology, Faculty of Medicine, Izmir University of Economics, Izmir, Türkiye

DOI: https://doi.org/10.1515/tjb-2023-0017
Journal volume & issue: Vol. 48, no. 3
pp. 311 – 318

Abstract

Read online

Inflammation can be endogenously modulated by the cholinergic anti-inflammatory pathway via calcium (Ca2+)-permeable alpha-7 nicotinic acetylcholine receptor (α7nAChR) ion channel expressed in immune cells. α7nAChR agonist choline and tryptophan metabolite kynurenic acid (KYNA) produces immunomodulatory effects. This study aimed to determine the effects of the choline and KYNA on the lipopolysaccharide (LPS)-induced cyclooxygenase (COX)-2 pathway.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

About the journal

Abstract

Keywords