Nature Communications (Jul 2022)
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment
- Kai Markus Schneider,
- Antje Mohs,
- Wenfang Gui,
- Eric J. C. Galvez,
- Lena Susanna Candels,
- Lisa Hoenicke,
- Uthayakumar Muthukumarasamy,
- Christian H. Holland,
- Carsten Elfers,
- Konrad Kilic,
- Carolin Victoria Schneider,
- Robert Schierwagen,
- Pavel Strnad,
- Theresa H. Wirtz,
- Hanns-Ulrich Marschall,
- Eicke Latz,
- Benjamin Lelouvier,
- Julio Saez-Rodriguez,
- Willem de Vos,
- Till Strowig,
- Jonel Trebicka,
- Christian Trautwein
Affiliations
- Kai Markus Schneider
- Department of Medicine III, University Hospital RWTH Aachen
- Antje Mohs
- Department of Medicine III, University Hospital RWTH Aachen
- Wenfang Gui
- Department of Medicine III, University Hospital RWTH Aachen
- Eric J. C. Galvez
- Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School
- Lena Susanna Candels
- Department of Medicine III, University Hospital RWTH Aachen
- Lisa Hoenicke
- Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School
- Uthayakumar Muthukumarasamy
- Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School
- Christian H. Holland
- Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital
- Carsten Elfers
- Department of Medicine III, University Hospital RWTH Aachen
- Konrad Kilic
- Department of Medicine III, University Hospital RWTH Aachen
- Carolin Victoria Schneider
- Department of Medicine III, University Hospital RWTH Aachen
- Robert Schierwagen
- European Foundation for the Study of Chronic Liver Failure (EF-CLIF)
- Pavel Strnad
- Department of Medicine III, University Hospital RWTH Aachen
- Theresa H. Wirtz
- Department of Medicine III, University Hospital RWTH Aachen
- Hanns-Ulrich Marschall
- Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg
- Eicke Latz
- Institute of Innate Immunity, Medical Faculty, University of Bonn
- Benjamin Lelouvier
- Vaiomer SAS
- Julio Saez-Rodriguez
- Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital
- Willem de Vos
- Laboratory of Microbiology, Wageningen University
- Till Strowig
- Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School
- Jonel Trebicka
- European Foundation for the Study of Chronic Liver Failure (EF-CLIF)
- Christian Trautwein
- Department of Medicine III, University Hospital RWTH Aachen
- DOI
- https://doi.org/10.1038/s41467-022-31312-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Steatohepatitis is a chronic hepatic inflammation associated with increased risk of hepatocellular carcinoma progression. Here the authors show that intestinal dysbiosis in mice lacking the inflammasome sensor molecule NLRP6 aggravates steatohepatitis and accelerates liver cancer progression, a process that can be delayed by antibiotic treatment.
