Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation

Renee Brady-Nicholls; John D. Nagy; Travis A. Gerke; Tian Zhang; Andrew Z. Wang; Jingsong Zhang; Robert A. Gatenby; Heiko Enderling

doi:10.1038/s41467-020-15424-4

Nature Communications (Apr 2020)

Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation

Renee Brady-Nicholls,
John D. Nagy,
Travis A. Gerke,
Tian Zhang,
Andrew Z. Wang,
Jingsong Zhang,
Robert A. Gatenby,
Heiko Enderling

Affiliations

Renee Brady-Nicholls: Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute
John D. Nagy: Department of Life Sciences, Scottsdale Community College
Travis A. Gerke: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute
Tian Zhang: Division of Medical Oncology, Department of Medicine, Duke Cancer Institute
Andrew Z. Wang: Department of Radiation Oncology, University of North Carolina at Chapel Hill
Jingsong Zhang: Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute
Robert A. Gatenby: Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute
Heiko Enderling: Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute

DOI: https://doi.org/10.1038/s41467-020-15424-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

Prostate specific antigen (PSA) is a biomarker for prostate cancer. Here, the authors develop a mathematical model where longitudinal changes in PSA levels predict responses to intermittent androgen deprivation in patients with prostate cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal