Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

Oh Youn Kim; Hyun Taek Park; Nhung Thi Hong Dinh; Seng Jin Choi; Jaewook Lee; Ji Hyun Kim; Seung-Woo Lee; Yong Song Gho

doi:10.1038/s41467-017-00729-8

Nature Communications (Sep 2017)

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

Oh Youn Kim,
Hyun Taek Park,
Nhung Thi Hong Dinh,
Seng Jin Choi,
Jaewook Lee,
Ji Hyun Kim,
Seung-Woo Lee,
Yong Song Gho

Affiliations

Oh Youn Kim: Department of Life Sciences, Pohang University of Science and Technology
Hyun Taek Park: Department of Life Sciences, Pohang University of Science and Technology
Nhung Thi Hong Dinh: Department of Life Sciences, Pohang University of Science and Technology
Seng Jin Choi: Department of Life Sciences, Pohang University of Science and Technology
Jaewook Lee: Department of Life Sciences, Pohang University of Science and Technology
Ji Hyun Kim: Department of Life Sciences, Pohang University of Science and Technology
Seung-Woo Lee: Department of Life Sciences, Pohang University of Science and Technology
Yong Song Gho: Department of Life Sciences, Pohang University of Science and Technology

DOI: https://doi.org/10.1038/s41467-017-00729-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Bacterial outer membrane vesicles (OMVs) contain immunogens but no study has yet examined their potential in treating cancer. Here, the authors demonstrate that OMVs can suppress established tumours and prevent tumour metastasis by an interferon-γ mediated antitumor response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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