Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

Qi Han; Josue D. Ordaz; Nai-Kui Liu; Zoe Richardson; Wei Wu; Yongzhi Xia; Wenrui Qu; Ying Wang; Heqiao Dai; Yi Ping Zhang; Christopher B. Shields; George M. Smith; Xiao-Ming Xu

doi:10.1038/s41467-019-13854-3

Nature Communications (Dec 2019)

Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

Qi Han,
Josue D. Ordaz,
Nai-Kui Liu,
Zoe Richardson,
Wei Wu,
Yongzhi Xia,
Wenrui Qu,
Ying Wang,
Heqiao Dai,
Yi Ping Zhang,
Christopher B. Shields,
George M. Smith,
Xiao-Ming Xu

Affiliations

Qi Han: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Josue D. Ordaz: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Nai-Kui Liu: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Zoe Richardson: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Wei Wu: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Yongzhi Xia: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Wenrui Qu: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Ying Wang: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Heqiao Dai: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine
Yi Ping Zhang: Norton Neuroscience Institute, Norton Healthcare
Christopher B. Shields: Norton Neuroscience Institute, Norton Healthcare
George M. Smith: Department of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine, Temple University
Xiao-Ming Xu: Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-13854-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Neurotrophin-3 (NT-3) plays a key role in the growth, development, and function of the nervous system. Here the authors show that NT-3-induced propriospino-motoneuron circuit reorganization is critical for locomotor recovery in mice following spinal cord injury.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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