Fabrication and properties of hydroxyapatite/chitosan composite scaffolds loaded with periostin for bone regeneration
Huachun Wang,
Ruixue Sun,
Shengyun Huang,
Haiwei Wu,
Dongsheng Zhang
Affiliations
Huachun Wang
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 250012, China; Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Qingdao, 266035, China
Ruixue Sun
College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China
Shengyun Huang
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250012, China
Haiwei Wu
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250012, China
Dongsheng Zhang
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 250012, China; Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250012, China; Corresponding author.Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 250012, China.
This paper reports a facile fabrication method of hydroxyapatite/chitosan (HAp/CS) composite scaffold with 3D porous structure without using any chemical cross-linkers. The HAp particles had an urchin-like hollow microstructure and high surface area, which was uniformly dispersed into the pore walls of the HAp/CS scaffold. The addition of HAp can efficiently enhance the mechanical properties and bioactivity of the HAp/CS scaffold. Moreover, periostin was successfully loaded onto the HAp/CS scaffold. When applied to the repair of bone defect in a rat mandibular model, the HAp/CS scaffold loaded with periostin can enhance osteointegration and accelerate bone regeneration. Our research combines periostin with the HAp/CS composite material, which provides a novel strategy to improve bone regeneration and has great application prospect in bone repair fields.
