Generation of an iPSC line from a 79-year-old female patient diagnosed with sporadic Parkinson’s disease

Jingrui Liu; Juan Du; Xiaowei Ma; Yuchuan Jin; Qian Yang; Yingtong Zhai; Jingke Cheng; Feng Luan; Min Ma; Zhanchi Zhang; Qian Ren; Huixian Cui

Stem Cell Research (Aug 2024)

Generation of an iPSC line from a 79-year-old female patient diagnosed with sporadic Parkinson’s disease

Jingrui Liu,
Juan Du,
Xiaowei Ma,
Yuchuan Jin,
Qian Yang,
Yingtong Zhai,
Jingke Cheng,
Feng Luan,
Min Ma,
Zhanchi Zhang,
Qian Ren,
Huixian Cui

Affiliations

Jingrui Liu: International Cooperation Laboratory of Stem Cell Research, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China; Department of Otolaryngology, The Third Hospital of Hebei Medical University, Shijiazhuang 050017, China
Juan Du: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; Human Brain Bank, Hebei Medical University, Shijiazhuang, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, China
Xiaowei Ma: Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
Yuchuan Jin: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; Human Brain Bank, Hebei Medical University, Shijiazhuang, China
Qian Yang: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; Human Brain Bank, Hebei Medical University, Shijiazhuang, China
Yingtong Zhai: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; International Cooperation Laboratory of Stem Cell Research, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China
Jingke Cheng: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; International Cooperation Laboratory of Stem Cell Research, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China
Feng Luan: Department of Otolaryngology, The Third Hospital of Hebei Medical University, Shijiazhuang 050017, China
Min Ma: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, China
Zhanchi Zhang: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, China
Qian Ren: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; International Cooperation Laboratory of Stem Cell Research, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, China; Corresponding authors.
Huixian Cui: Department of Human Anatomy, Hebei Medical University, Shijiazhuang 050017, China; International Cooperation Laboratory of Stem Cell Research, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, China; Corresponding authors.

Journal volume & issue: Vol. 78
p. 103450

Abstract

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Parkinson’s disease is a common neurodegenerative disorder. Here we present a human induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient diagnosed with sporadic Parkinson’s disease using the sendai virus. Generated iPSCs maintain normal karyotype, exhibit pluripotent stem cell markers, and possess differentiation potential. The iPSCs allows for differentiation into various cell subtypes, providing conditions for the research of the pathogenesis and drug development of Parkinson’s disease.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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