Nature Communications (Aug 2021)

A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

  • Bei Liu,
  • Honglue Shi,
  • Atul Rangadurai,
  • Felix Nussbaumer,
  • Chia-Chieh Chu,
  • Kevin Andreas Erharter,
  • David A. Case,
  • Christoph Kreutz,
  • Hashim M. Al-Hashimi

DOI
https://doi.org/10.1038/s41467-021-25253-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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m6A RNA post-transcriptional modification changes RNA hybridization kinetics. Here the authors show that the methylamino group can adopt syn-conformation pairing with uridine with a mismatch-like conformation in RNA duplex. They also develop a quantitative model that predicts how m6A affects the kinetics of hybridization.