Communications Biology (Aug 2021)

Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone

  • Douglas K. Reilly,
  • Emily J. McGlame,
  • Elke Vandewyer,
  • Annalise N. Robidoux,
  • Caroline S. Muirhead,
  • Haylea T. Northcott,
  • William Joyce,
  • Mark J. Alkema,
  • Robert J. Gegear,
  • Isabel Beets,
  • Jagan Srinivasan

DOI
https://doi.org/10.1038/s42003-021-02547-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 16

Abstract

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Reilly et al identify a neuropeptide-neuropeptide receptor (NP/NPR) module that is active in male but not in hermaphrodite C. elegans. Using a neuropeptide rescue paradigm, they demonstrate that receptor expression within pre-motor neurons mediates coordination of male-specific and core locomotor circuitries.