1017 SLAMF7+ CD8+ exhausted T cell-specific gene signature is associated with resistance to PD1 blockade in renal cell carcinoma

• Michael Hurwitz,
• Elizabeth Plimack,
• Jeffrey Sosman,
• Sabina Signoretti,
• David F McDermott,
• Michael B Atkins,
• Naomi B Haas,
• Hans Hammers,
• Nicholas Schindler,
• Opeyemi A Jegede,
• Catherine J Wu,
• David Braun,
• Miya Hugaboom,
• Kelly Street,
• Neil Ruthen,
• Lena Wirth

Affiliations

Michael Hurwitz

1 Yale Cancer Center, New Haven, Connecticut, USA

Elizabeth Plimack

Aff251 grid.412530.10000000404566466Fox Chase Cancer Center Philadelphia PA USA

Jeffrey Sosman

Department of Hematology and Oncology, Northwestern University, Evanston, Illinois, USA

Sabina Signoretti

13Brigham and Women’s Hospital, Boston, MA, USA

David F McDermott

5Beth Israel Deaconess Medical Center, Boston, MA, USA

Michael B Atkins

1 Georgetown University, Washington, District of Columbia, USA

Naomi B Haas

7Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

Hans Hammers

Aff3 grid.21107.350000000121719311Kimmel Cancer Center, Johns Hopkins School of Medicine Baltimore MD USA

Nicholas Schindler

1Yale School of Medicine, New Haven, CT, USA

Opeyemi A Jegede

3Dana-Farber Cancer Institute, Boston, MA, USA

Catherine J Wu

Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

David Braun

Medical Oncology, Yale School of Medicine, New Haven, Connecticut, USA

Miya Hugaboom

1Yale School of Medicine, New Haven, CT, USA

Kelly Street

2Keck School of Medicine of USC, Los Angeles, CA, USA

Neil Ruthen

3Dana-Farber Cancer Institute, Boston, MA, USA

Lena Wirth

1Yale School of Medicine, New Haven, CT, USA